Category: Annual Grant Scheme

‘Multiomic characterization of ocular graft versus host disease from patient tears’ Dr. Emily Grennan

Annual Grant Scheme 2021 Haematopoietic stem cell transplantation (HSCT) is a potentially curative form of treatment for a wide range of haematological diseases, including lymphoma, leukaemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. However, with the increase survival has come an increase in chronic complications, predominately that of graft versus host … Continued

‘NOTCH1 Mutations in Adenoid Cystic Carcinoma’ Dr. Ross O’Sheaw

Annual Grant Scheme 2021 Adenoid cystic carcinomas (ACC) are rare salivary gland neoplasms identified within the major and minor salivary glands, predominantly the parotid gland and palate. ACC account for approximately 10% of all salivary gland neoplasms. Interestingly, ACC can occur at other anatomic sites outside the head and neck region including within breast tissue … Continued

‘Tumour Infiltrating Lymphocytes and Programmed Cell Death Ligand-1 as Prognostic Indicators in Human Papillomavirus Associated Oropharyngeal Cancer’ Dr. Grace O’Flanagan

Annual Grant Scheme 2020 It is well established that human papilloma virus (HPV) associated oropharyngeal cancer (OPC) carries a favourable prognosis compared to non-HPV associated OPC. This is reflected in the most recent (8th) edition of the American Joint Committee on Cancer (AJCC) staging manual wherein HPV+OPC has a distinct TNM classification. Thus there exists … Continued

‘Establishing a two- and three-dimensional model of inflammatory dry eye disease to test novel therapeutics using primary human conjunctival epithelial cells and limbal stem cells.’ Dr. Emily Grennan

Annual Grant Scheme 2020 Dry eye disease (DED) is an extremely common condition, affecting 5-50% of the worldwide population. For those affected, symptoms can be chronic and progressive ranging from mild irritation, grittiness and stinging to debilitating painful and potentially sight threatening. Furthermore, currently available medications used to treat DED fall short of providing a … Continued

‘Genotype-Phenotype correations of patients with ABCA4 mutations seen at the Royal Victoria Eye and Ear Hospital’, Dr. Niamh Wynne

There are an estimated 5000 patients in Ireland suffering from an inherited retinal disease (IRD). The goal of our collaborative study ‘Target 5000’,  through genetic diagnosis, to better enable these 5000 individuals to obtain a clearer understanding of their condition and improved access to potentially life changing therapies. There are up to 800 people living … Continued

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